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Why This Comparison Matters Growth hormone production declines roughly 14% per decade after age 30

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Surgery is typically saved as the last resort if patients do not respond to other treatment methods

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The interaction between interleukin-22 and interleukin-17 inhibits keratinocyte differentiation while increasing their proliferation and motility, leading to nuclear retention within the stratum corneum, epidermal hyperplasia (acanthosis), and elongation of the epidermal rete ridges (papillomatosis) all of which are characterized by psoriatic skin plaques (Becher and Pantelyushin 2012)